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Bitter compounds stimulate GLP-1 secretion via taste receptors in the gut

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Michael Camilleri, a gastroenterologist at Mayo Clinic who has published extensively on GLP-1 effects on gut motility, has noted: "The delayed gastric emptying from GLP-1 agonists is a pharmacologic effect, not a pathologic gastroparesis

Since cells expressing both receptors appear to have glutamatergic expression as well, this would suggest that this pathway acts separately from these other well-characterized GABAergic output pathways

[Last cited in 2009]

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