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Similarly, other previous studies found that retinal venular widening correlated with an increased risk of CKD progression in T2DM patients, highlighting the retina's predictive value (137, 138)

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16, 21 Therefore, we have undertaken extensive studies to determine the potential for BSO to enhance the anti-myeloma activity of L-PAM at clinically achievable doses using in vitro (cell lines and fresh MM explants) and in vivo MM xenografts to determine if BSO+L-PAM warrants clinical trials in MM

Also, several pathogenic mechanisms linked to ALS involve redox-sensitive proteins, including protein disulfide isomerase (PDI), thioredoxin, and glutathione (GSH), and recent evidence highlights their importance in neurodegeneration

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Understanding Liver Health and Oxidative Stress The liver is your body's primary detoxification organ, processing everything from medications to environmental toxins