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Secondary immunodeficiency was found in 10% of patients with RA It was more common in patients with earlier RA onset, seronegative disease and rituximab exposure Whole-exome sequencing identified 17 putatively pathogenic rare variants in inborn errors of immunity (IEI)-associated genes in 15 of 70 patients 41.2% of variants affected genes involved in canonical NF-B signalling Two patients harboured variants previously reported as pathogenic The findings suggest that, in a subset of patients, immunodeficiency may not be explained by immunomodulatory therapy alone
