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Warning signs that require prompt assessment include: Persistent vomiting that prevents adequate fluid or medication intake Inability to maintain nutrition or hydration Severe abdominal pain (which could indicate pancreatitis, gallbladder disease, or other serious conditions) Vomiting of undigested food consumed many hours previously Significant unintended weight loss Worsening glycaemic control despite medication adherence It is worth noting that symptoms alone cannot definitively distinguish between expected medication effects and true gastroparesis

doi: 10.1038/nri2448 24 ZhouJTangZGaoSLiCFengYZhouX

In the pre-specified 104-week extension, participants on 12 mg reached an average of -30.3% (-85.0 lbs / -38.5 kg) , with no weight-loss plateau observed