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For individuals with diabetes or prediabetes, these effects reduce A1C levels, improve insulin sensitivity, and decrease the physiologic drive to overeat in response to unstable glucose patterns

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However, the use of BM-MSCs, especially autologous ones, is constrained by the invasiveness of the procedure, the extended duration required for cell culture and preparation (approximately two months), the high cost and difficulty to obtain an adequate dose of cells from a single recipient, and the heterogeneity of cells due to variations in donors age, gender, genetics, and health conditions [313]

doi:10.2106/00004623-198466010-00009