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Abbreviations ACC: acetyl-CoA carboxylase AMPK: adenosine monophosphate-activated protein kinase GSIS: glucose-stimulated insulin secretion HDL-C: high-density lipoprotein cholesterol H&E: hematoxylin and eosin LDL-C: low-density lipoprotein cholesterol LETO: Long-Evans Tokushima Otsuka OLETF: Otsuka Long-Evans Tokushima Fatty T2DM: type 2 diabetes mellitus TC: total cholesterol TG: triglyceride References Bieri J, Stoewsand G, Briggs G, Phillips, Woodard RJ, Knapka J

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