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Because of its rapid degradation and removal from the body, giving GLP-1 as a therapy was unsuccessful

58 Mitochondrial bioenergetics are also stimulated by the H 2 S-generating 3-MST substrate 3-MP (Table 1) both in the murine colon cancer CT26 cell line 147 and in mouse hepatoma cells, 148 where silencing of 3-MST or SQR decreased basal cellular bioenergetics, further suggesting that mitochondrial bioenergetics are partially sustained by SQR-mediated H 2 S oxidation (Table 1)