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It belongs to a class of medications called dual GIP/GLP-1 receptor agonists, which work by activating two hormone pathways: the GIP pathway and the GLP-1 pathway

Retatrutide Side Effects Are Similar to Existing Diabetes and Obesity Injectables The most common side effects for retatrutide were: Nausea (16 to 27 percent of participants, depending on dosage, compared with 3.7 percent of those taking a placebo) Diarrhea (19 to 23 percent, compared with 5 percent taking a placebo) Vomiting (16 to 18 percent, compared with 2 percent taking a placebo) Nerve issues (2 to 4 percent, compared with none taking a placebo) Between 2 and 5 percent of participants on retatrutide stopped taking it before the trial ended, with a greater risk of stopping among those who took the highest dose

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Side Effect Profiles: What to Expect Both oral and injectable tirzepatide interact with the digestive system, which means they share a similar list of potential side effects

The SURMOUNT trials further confirmed tirzepatide's weight loss effects, leading to its FDA approval as a treatment for weight management [7, 8, 9, 10]

Understanding that mild nausea is a normal side effect is essential