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Working with autoimmune cases for many years, there are several underlying factors that seem to always play a significant role

The lysates were centrifuged at 12,000 g and 4 C for 10 min

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DECLARATIONS Acknowledgments The authors would like to thank the Neurobiology Research Group of the University of Valladolid, and the Department of Cellular Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid (Spain) for their collaboration in carrying out the review

It is a process in which cells sequester the autophagic cargoes within double-membrane vesicular structures, named autophagosomes, which finally fuse with lysosomes, where sequestered materials are degraded and recycled for reuse (Yang et al., 2008