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Patients with specific genetic predispositions in GLP-1R, GIPR, and FTO pathways may experience different efficacy trajectories, making genetic context essential for informed cost-benefit analysis and provider conversations about treatment selection

Wegovy 7.2 mg The STEP UP trial found that patients on Wegovy 7.2 mg lost an average of 20.7% of their body weight after 72 weeks, compared with 17.5% on the standard 2.4 mg dose

Although 35 month-old mutants and controls habituated similarly, 810 month-old mutants showed an altered response to the testing environment and were unable to habituate (Fig

it can also be a critical factor in how well the medication works and how manageable the side effects are

A related formulation, Wegovy (also semaglutide but at higher doses), has been licensed specifically for weight management in adults with obesity (NICE TA875)