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Keeping the area cool and avoiding direct sunlight helps calm this down

doi: 10.1096/FJ.02-0566FJE 153 MishraPPaitalBJenaSSwainSSKumarSYadavMKet al

231,232 These modifications alter gene expression and protein function, causing vascular dysfunction, inflammation, and oxidative stress, all of which contribute to the pathogenesis of DPN