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Evening dosing is preferred because it aligns with the bodys natural circadian rhythm of growth hormone release, which peaks at night during deep sleep

After dose increases, the cycle often repeats briefly, then settles again

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These effects were particularly strong during the initial phase of treatment, and sustained suppression of food intake and weight loss continued throughout the three-week evaluation period

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Case reports of tirzepatide-associated thyroiditis A published case report described a 32-year-old woman with no personal or family history of thyroid disease who developed painless biphasic thyroiditis after two months of tirzepatide therapy