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Compared to insulin glargine, tirzepatide reduces the prevalence of the metabolic syndrome in patients with type 2 diabetes and high cardiovascular risk: Post-hoc analysis of SURPASS-4

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It functions by targeting certain hormones that regulate appetite and insulin secretion, aiding in the management of food intake and blood sugar levels

Mechanism of Action When SLU-PP-332 binds to ERR, it activates transcriptional programs normally triggered by endurance exercise, including: Upregulation of PGC-1, the master regulator of mitochondrial gene expression Increased mitochondrial density and oxidative enzyme activity in skeletal and cardiac muscle Enhanced fatty acid oxidation and energy expenditure Improved substrate utilization, as indicated by reduced respiratory exchange ratio (RER) in animal studies

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