Rat Mesencephalic Astrocyte-derived Neurotrophic Factor, MANF ELISA Kit, 96T Filtration This protein also plays a

This protein also plays a role in cell proliferation

Phosphorylates BCL2L1

A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis

In addition to histone acetylation

Exhibits aminopeptidase activity against neurogranin in vitro

Rat Mesencephalic Astrocyte-derived Neurotrophic Factor, MANF ELISA Kit, 96T Filtration This protein also plays aSelectively promotes the survival of dopaminergic neurons of the ventral mid brain (By similarity). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (PubMed: 16462600). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (PubMed: 16462600). Inhibits cell proliferation and endoplasmic reticulum (ER) stress induced cell death (By similarity). Retained in the ER