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MDM2 Polyclonal Antibody, 20ul[BT-AP05301] Purification which is mutated in adenomatous

SKU: 15486135203

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MDM2 Polyclonal Antibody, 20ul[BT-AP05301] Purification which is mutated in adenomatousMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many

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Description

which is mutated in adenomatous polyposis of the colon

and this interaction may play a role in ovulation and fertilization

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and may play a catalytic role in the function of the SMN complex on RNPs

kidney and muscle

MDM2 Polyclonal Antibody, 20ul[BT-AP05301] Purification which is mutated in adenomatousMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many

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