MIB2 Polyclonal Antibody, 100ul Modification Enzymes This gene belongs to the
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MIB2 Polyclonal Antibody, 100ul Modification Enzymes This gene belongs to theE3 ubiquitin protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction: Down regulated in many primary skin melanomas. Treatment with a demethylating agent, 5' aza 2 deoxycytidine, restores expression, suggesting that down regulation is the result
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