UBE2K Polyclonal Antibody, 20ul Subcellular Fractions Two alternatively spliced transcript variants

Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247

The encoded protein is predicted to contain 6 to 10 transmembrane domains| and a leucine zipper motif in transmembrane domain III

and are involved in a variety of biological processes

|induction:Regulated by cellular iron levels through binding of the iron regulatory proteins| IRP1 and IRP2| to iron-responsive elements in the 3'-UTR

GAPs stimulate the intrinsic GTP hydrolysis of small G proteins

UBE2K Polyclonal Antibody, 20ul Subcellular Fractions Two alternatively spliced transcript variantsThe protein encoded by this gene belongs to the ubiquitin conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains