Mouse DNA Topoisomerase 1, TOP1 ELISA Kit, 96T Enzymes Expression of the mouse homolog

Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling

The protein encoded by this gene belongs to the UDP-glycosyltransferase family

Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure

Binds to a consensus sequence in gene promoters (By similarity)

extracellular matrix proteases modulating their activity

Mouse DNA Topoisomerase 1, TOP1 ELISA Kit, 96T Enzymes Expression of the mouse homologReleases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA (3' phosphotyrosyl) enzyme intermediate and the expulsion of a 5' OH