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PRAK Polyclonal Antibody, 50ul[BT-AP07382] Dialysis It is located in the

SKU: 22221303896

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PRAK Polyclonal Antibody, 50ul[BT-AP07382] Dialysis It is located in theThe protein encoded by MAPKAPK5 (mitogen activated protein kinase activated protein kinase 5) is a tumor suppressor and member of the serine threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1 ERK, MAPK14 p38 alpha, and MAPK11 p38 beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation

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Description

It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus

This protein plays a role in promoting ionizing radiation-induced apoptosis

Experimental confirmation may be lacking for some isoforms|disease:Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA)

Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors

This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression

PRAK Polyclonal Antibody, 50ul[BT-AP07382] Dialysis It is located in theThe protein encoded by MAPKAPK5 (mitogen activated protein kinase activated protein kinase 5) is a tumor suppressor and member of the serine threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1 ERK, MAPK14 p38 alpha, and MAPK11 p38 beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation

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