DERL1 Polyclonal Antibody, 20ul Cell Function Analysis PKP2 encodes a member of

PKP2 encodes a member of the arm-repeat (armadillo) and plakophilin gene families

The encoded protein is found to be associated with centromeres of mitotic HeLa cells| which suggests that this protein is a functional homolog of yeast Nuf2

The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA

A similar protein in budding yeast is a component of pre-60S ribosomal particles| and is required for the early maturation steps of the 60S subunit

This enzyme can also use myo-inositol-1|3-diphosphate| myo-inositol-1|4-diphosphate| scyllo-inositol-phosphate| glucose-1-phosphate| glucose-6-phosphate| fructose-1-phosphate| beta-glycerophosphate| and 2'-AMP as substrates

DERL1 Polyclonal Antibody, 20ul Cell Function Analysis PKP2 encodes a member ofThe protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance