Tau(Phospho Ser516/199) Polyclonal Antibody, 20ul Sealing Film Constitutive activation of PRKACA caused

Constitutive activation of PRKACA caused either by somatic mutations

Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene

with some of them functioning as activators and some as repressors of transcription

with strong preference for histone H4

Shd (SH2 domain-containing adapter protein d)

Tau(Phospho Ser516/199) Polyclonal Antibody, 20ul Sealing Film Constitutive activation of PRKACA causedThis gene encodes the microtubule associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia,