Raf-1(Phospho Ser43) Polyclonal Antibody, 20ul Contamination Detection & Removal Mutations in this gene result

Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus

Transcript variants encoding different preproprotein isoforms have been described for this gene

Both of these embryonic hemoglobins are normally supplanted by fetal

and inhibits bone morphogenetic protein (BMP) function

Transcripts initiating from the downstream promoter encode beta isoforms

Raf-1(Phospho Ser43) Polyclonal Antibody, 20ul Contamination Detection & Removal Mutations in this gene resultThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.