Cathepsin E Polyclonal Antibody, 50ul Bio-Reaction Tube Genome-wide association studies have linked

Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes

This gene was originally isolated based on its deletion in a medulloblastoma cell line

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Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes

The encoded protein contains three leucine-rich repeat motifs

Cathepsin E Polyclonal Antibody, 50ul Bio-Reaction Tube Genome-wide association studies have linkedCTSE encodes a member of the A1 family of peptidases. Alternative splicing of CTSE results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme (cathepsin E), an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of CTSE has been observed in neurodegeneration.