Topo I Polyclonal Antibody, 20ul Culture Media The encoded protein is a

The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation

and also belongs to the immunoglobulin superfamily

A single amino acid substitution is responsible for an activating mutation

10 (MAGEA10) gene

These proteins also share structural homology with TNF family members

Topo I Polyclonal Antibody, 20ul Culture Media The encoded protein is aTOP1 (topoisomerase (DNA) I) encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. TOP1 is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.