MYLK Polyclonal Antibody, 100ul[BT-AP05707] Endonucleases & Exonucleases The alpha gene cluster is

The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences

and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease

Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein| and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1

for this protein

Because of its increase due to acute inflammation| this protein is classified as an acute-phase reactant

MYLK Polyclonal Antibody, 100ul[BT-AP05707] Endonucleases & Exonucleases The alpha gene cluster isMYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. MYLK encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein