AKT mouse Monoclonal Antibody(1E11), 50ul Protein Post-translational Modification Two alternative transcript variants encoding

Two alternative transcript variants encoding different protein isoforms have been described for this gene

This receptor is especially abundant in hematologic tissues

Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified

An important paralog of this gene is DCX

and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane

AKT mouse Monoclonal Antibody(1E11), 50ul Protein Post-translational Modification Two alternative transcript variants encodingThe serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3 kinase. In the developing nervous system AKT is a