PEN2 Rabbit Polyclonal Antibody, 50ul Plates & Dishes Autoantibodies against the encoded protein

Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes

Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation

and stimulates interferon gamma production in T-helper type I cells

SMC3 and either SMC1B or the protein encoded by this gene

PEN2 Rabbit Polyclonal Antibody, 50ul Plates & Dishes Autoantibodies against the encoded proteinPresenilins which are components of the gamma secretase protein complex are required for intramembranous processing of some type I transmembrane proteins such as the Notch proteins and the beta amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta amyloid precursor protein generates neurotoxic amyloid beta peptides the major component of senile plaques associated with