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Rat Nf-Kappa-B Inhibitor Alpha, NFKBIA ELISA Kit, 96T Reservoirs Interacts directly with BNIP1/SEC20L and

SKU: 32953482093

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Rat Nf-Kappa-B Inhibitor Alpha, NFKBIA ELISA Kit, 96T Reservoirs Interacts directly with BNIP1/SEC20L andInhibits the activity of dimeric NF kappa B REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity).

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Description

Interacts directly with BNIP1/SEC20L and ZW10

Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (PubMed: 25200183)

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors

This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor B

Isoform 3 may play a role in early spermatogenesis

Rat Nf-Kappa-B Inhibitor Alpha, NFKBIA ELISA Kit, 96T Reservoirs Interacts directly with BNIP1/SEC20L andInhibits the activity of dimeric NF kappa B REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity).

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