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Phospho-AIRE-1 (S156) Polyclonal Antibody, 100ul Liquid Handling &Storage Component of the probable ECS(SPSB1)

SKU: 35113660564

4.1
USD141.00 USD190.00

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Phospho-AIRE-1 (S156) Polyclonal Antibody, 100ul Liquid Handling &Storage Component of the probable ECS(SPSB1)AIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The autoimmune regulator plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T cells in the thymus. Mutations in this gene cause the rare autosomal recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and

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Description

Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1

probably playing a role in regulating LPS-dependent monocyte responses

and is resistant to harsh chemicals

The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome

Two molecules of each of the four core histones (H2A| H2B| H3| and H4) form an octamer| around which approximately 146 bp of DNA is wrapped in repeating units| called nucleosomes

Phospho-AIRE-1 (S156) Polyclonal Antibody, 100ul Liquid Handling &Storage Component of the probable ECS(SPSB1)AIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The autoimmune regulator plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T cells in the thymus. Mutations in this gene cause the rare autosomal recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and

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