TH Polyclonal Antibody, 50ul[BT-AP08990] Cellular Cultivation & Health Management The G protein-coupled receptor 119

The G protein-coupled receptor 119 is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis

It also contains a coiled-coil domain| a collagen-like domain| two nuclear localization signals| and several potential PKC and PKA phosphorylation sites

6-biphosphate levels through the activity of 6-phosphofructo-2-kinase/fructose-2

and a 35 kD subunit encoded by IL12A

The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors| inositol 1|4|5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling| T-cell activation and trafficking of amyloid beta peptides

TH Polyclonal Antibody, 50ul[BT-AP08990] Cellular Cultivation & Health Management The G protein-coupled receptor 119Tyrosine 3 monooxygenase encoded by TH is involved in the conversion of tyrosine to dopamine. It is the rate limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.