11 Beta-HSD1 Polyclonal Antibody, 100ul[BT-AP00002] Adeno-associated Virus Packaging This gene is localized to

This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers

The specific functions of these proteins have not been determined| but they are thought to be involved in sperm maturation

Hyperphosphorylation of Rb proteins results in a loss of E2F binding and allows for transcriptional activation and cell cycle progression

It is included in a cluster of homeobox D genes located on chromosome 2

Two splice variants encoding different isoforms have been found for this gene

11 Beta-HSD1 Polyclonal Antibody, 100ul[BT-AP00002] Adeno-associated Virus Packaging This gene is localized tohydroxysteroid 11 beta dehydrogenase 1(HSD11B1) Homo sapiens The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and