p21 (Acetyl Lys161/K163) Rabbit Polyclonal Antibody, 50ul Polyclonal Antibodies Several alternatively spliced transcript variants
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p21 (Acetyl Lys161/K163) Rabbit Polyclonal Antibody, 50ul Polyclonal Antibodies Several alternatively spliced transcript variantsMay be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin dependent kinase activity preventing phosphorylation of critical cyclin dependent kinase substrates and blocking cell cycle progression. induction: By p53 mezerein (antileukemic compound) and interferon beta. PTM: Phosphorylation of Thr 145 by Akt or of Ser 146 by PKC impairs binding to
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