Mouse E3 Ubiquitin-protein Ligase Parkin, PARK2 ELISA Kit, 96T Plates & Dishes Lack of Dol-P-Man results in

Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins

The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin

Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed: 16866869

Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed: 25275521)

subunit:Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5

Mouse E3 Ubiquitin-protein Ligase Parkin, PARK2 ELISA Kit, 96T Plates & Dishes Lack of Dol-P-Man results inFunctions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed: 32047033, PubMed: 29311685). Substrates include SYT11 and VDAC1 (PubMed: 32047033, PubMed: 29311685). Other substrates are BCL2, CCNE1, GPR37, RHOT1 MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (By similarity). Mediates monoubiquitination as well as 'Lys 6', 'Lys