Vav(Phospho Tyr174) Polyclonal Antibody, 100ul NGS Oligos Mutations in this gene can

Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy)

Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14)

thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed: 21602804)

The SFPQ-NONO/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity

and AQP5 reside in a cluster on chromosome 12q13

Vav(Phospho Tyr174) Polyclonal Antibody, 100ul NGS Oligos Mutations in this gene canThis gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T cell and B cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV 1.