Rb Polyclonal Antibody, 100ul[BT-AP07691] sgRNA Oligos Instantly dissolve these granules for

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Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined

This gene encodes a single-pass membrane protein| which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily

This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins

NF-kappa-B p50 subunit interacts with NCOA3 coactivator| which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity

Rb Polyclonal Antibody, 100ul[BT-AP07691] sgRNA Oligos Instantly dissolve these granules forThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.