Raf-1(Phospho Ser642) Polyclonal Antibody, 50ul sgRNA customized design Mutations in this gene have

Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus

a disorder resulting in neuropathy

The protein can act as an autoantigen in pemphigus diseases

Proteolysis also occurs by way of CUL-4 associating with Nedd-8

The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex

Raf-1(Phospho Ser642) Polyclonal Antibody, 50ul sgRNA customized design Mutations in this gene haveThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.