Stat5 Polyclonal Antibody, 100ul[BT-AP08635] Molecular Weight Markers Dok-4 (Downstream of kinase-4) is

Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins

This gene contains three copies of the 10

This protein mediates the selective degradation of misfolded| unassembled or oxidatively damaged polypeptides in the mitochondrial matrix

this protein binds to a 4Fe-4S cluster and functions as an aconitase

This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance

Stat5 Polyclonal Antibody, 100ul[BT-AP08635] Molecular Weight Markers Dok-4 (Downstream of kinase-4) isStat5 is activated in response to a wide variety of ligands including IL 2, GM CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL 3, which suggests its involvement in angiogenesis and cell motility.