NMRL1 Rabbit Polyclonal Antibody, 50ul Enzyme Activity Assays The encoded protein is induced

The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses

Mutations in this gene are the most common cause of Fanconi anemia

Additional isoforms produced by alternative splicing seem to exist

This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK

Contains 5 WD repeats

NMRL1 Rabbit Polyclonal Antibody, 50ul Enzyme Activity Assays The encoded protein is inducedThis gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF kappaB in a ubiquitylation dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3 mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants.