Csk Monoclonal Antibody, 100ul Antibody Development Plays a role in positive

Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules

PHLDB2 and RSN

Directly associates with HAX1

Defects in this gene are the cause of immunodeficiency polyendocrinopathy

Contains 3 EGF-like domains

Csk Monoclonal Antibody, 100ul Antibody Development Plays a role in positivecatalytic activity: ATP + a [protein] L tyrosine = ADP + a [protein] L tyrosine phosphate.,function: Specifically phosphorylates 'Tyr 504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM: Autophosphorylation of Tyr 304 occurs only at abnormally high CSK concentrations in vitro.,similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity: Belongs to the protein kinase