p53 Polyclonal Antibody, 50ul[BT-AP06815] Site-directed Mutagenesis Isoform 1 has lower affinity

Isoform 1 has lower affinity for DNA

The protein encoded by this gene mediates sodium and chloride transport and reabsorption

The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium

The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin

p53 Polyclonal Antibody, 50ul[BT-AP06815] Site-directed Mutagenesis Isoform 1 has lower affinityTP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.