FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture that may share one or

that may share one or more domains in common

Two alternatively spliced transcript variants encoding distinct isoforms have been described

The encoded protein plays a role in the inducible expression of cytokine genes in T cells| especially in the induction of interleukin-2 and interleukin-4

An important paralog of this gene is SLC38A1

The protein is weakly similar to transposase-like proteins in human and mouse

FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture that may share one ordisease: A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X; 11)(q13; q23) with MLL HRX. The result is a rogue activator protein. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin response elements (IREs) and can activate transcription of IGFBP1. Down regulates expression of HIF1A and suppresses hypoxia induced transcriptional activation of HIF1A modulated genes.