RPGF6 Polyclonal Antibody, 20ul Custom Peptide Synthesis Multiple transcript variants encoding different

Multiple transcript variants encoding different isoforms have been found for ELAC2

Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation

including hereditary cancers such as Li-Fraumeni syndrome

The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation

giving rise to several mRNA species

RPGF6 Polyclonal Antibody, 20ul Custom Peptide Synthesis Multiple transcript variants encoding differentGuanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M Ras GTPases. Does not interact with cAMP.,PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.,Contains 1 cyclic nucleotide binding domain.,Contains 1 N terminal Ras GEF domain.,Contains 1 PDZ (DHR) domain.,Contains 1 Ras associating domain.,Contains 1 Ras GEF domain.,subcellular location: Upon binding to M Ras, it translocates to the plasma membrane.,subunit: Interacts with the