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NIPP1 Polyclonal Antibody, 20ul Contamination Detection & Removal FCRL5 is implicated in B

SKU: 63436505111

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PLN111.00 PLN150.00

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NIPP1 Polyclonal Antibody, 20ul Contamination Detection & Removal FCRL5 is implicated in BPPP1R8 (protein phosphatase 1 regulatory subunit 8), through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by PPP1R8 are specific inhibitors of type 1 serine threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its

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Description

FCRL5 is implicated in B cell development and lymphomagenesis

Mutations in LMNA lead to several diseases: emery-Dreifuss muscular dystrophy

and in T cell and B cell migration to secondary lymphoid organs

Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity

Four transcript variants encoding two different isoforms have been found for this gene

NIPP1 Polyclonal Antibody, 20ul Contamination Detection & Removal FCRL5 is implicated in BPPP1R8 (protein phosphatase 1 regulatory subunit 8), through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by PPP1R8 are specific inhibitors of type 1 serine threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its

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