TLR13 Polyclonal Antibody, 100ul NGS Oligos The ROS generated by family

The ROS generated by family members have been implicated in numerous biological functions including host defense

thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site

included the conserved Asp-Glu-Ala-Asp (DEAD) motif

like most family members

which may indicate this protein has a role in origin activation

TLR13 Polyclonal Antibody, 100ul NGS Oligos The ROS generated by familyThe TLRs form a family of ligand binding proteins that engage a variety of microbial products, that on binding, activate signaling cascades leading to the synthesis of proinflammatory molecules. TLR13 is found in mouse and participates in the innate immune response to microbial agents. It acts via MYD88 and TRAF6, leading to NF kappa B activation, cytokine secretion and the inflammatory response.