Mouse Neurogenic Locus Notch Homolog Protein 1, NOTCH1 ELISA Kit, 96T Antibodies in a cytoplasmic or membrane-associated
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Mouse Neurogenic Locus Notch Homolog Protein 1, NOTCH1 ELISA Kit, 96T Antibodies in a cytoplasmic or membrane-associatedFunctions as a receptor for membrane bound ligands Jagged 1 (JAG1), Jagged 2 (JAG2) and Delta 1 (DLL1) to regulate cell fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively
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