Stat4 Polyclonal Antibody, 50ul[BT-AP14541] Antibody Humanization Growth associated protein 43 encoded

Growth associated protein 43 encoded by GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration

This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner

Three transcript variants encoding two different isoforms have been described

Cleaves ubiquitin fusion protein substrates

Gene Ontology (GO) annotations related to this gene include DNA-directed DNA polymerase activity

Stat4 Polyclonal Antibody, 50ul[BT-AP14541] Antibody Humanization Growth associated protein 43 encodedThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.