Cytokeratin 17 Monoclonal Antibody, 100ul Bottles Mutations in this gene are

Mutations in this gene are associated with gastrointestinal stromal tumors

possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane

but this action is still debated

the mature protein downregulates fibrinolysis

Pseudogenes of this gene are located on the long arms of chromosomes 8| 10 and 12

Cytokeratin 17 Monoclonal Antibody, 100ul Bottles Mutations in this gene areThis gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson Lawler type pachyonychia congenita and steatocystoma multiplex.