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MDM2 Polyclonal Antibody, 50ul[BT-AP05300] Vacuum Aspirator SEPT11 belongs to the conserved

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MDM2 Polyclonal Antibody, 50ul[BT-AP05300] Vacuum Aspirator SEPT11 belongs to the conservedMDM2 encodes a nuclear localized E3 ubiquitin ligase. E3 ubiquitin protein ligase Mdm2 can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript

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Description

SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al

The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism

gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS)

PIAS1 encodes a member of the protein inhibitor of activated STAT (PIAS) family

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK)

MDM2 Polyclonal Antibody, 50ul[BT-AP05300] Vacuum Aspirator SEPT11 belongs to the conservedMDM2 encodes a nuclear localized E3 ubiquitin ligase. E3 ubiquitin protein ligase Mdm2 can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript

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