Phospho-ALK (Y1096) Polyclonal Antibody, 50ul In vitro Assessment It is mapped to chromosome

It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3

This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus

Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins

Gene expression is high during fetal development and in most tumors

but unlike BRCA1

Phospho-ALK (Y1096) Polyclonal Antibody, 50ul In vitro Assessment It is mapped to chromosomeALK encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. ALK tyrosine kinase receptor comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or