IKappaB-Epsilon Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection The protein encoded by this

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4|5-bisphosphate to 1D-myo-inositol 1|4|5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor

the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53

This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17

the minichromosome maintenance proteins (MCMs) and DNA polymerase

and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms

IKappaB-Epsilon Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection The protein encoded by thisThe protein encoded by NFKBIE binds to components of NF kappa B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF kappa B by making it available to translocate to the nucleus.